Endocrine Abstracts

Background: PD-1/PD-L1 blockade is one of the promising drugs in the treatment of advanced non-small cell lung cancer (NSCLC). and predicting drug effect is important due to unique pattern of response. Immune-related adverse event (IRAE) might be associated with favorable clinical outcome. Thyroiditis is the most common IRAE which can be easily detected with the measurement of thyroid hormone levels. However, the relationship between thyroid dysfunction during the use of PD-1/...

Background: Three deiodinase genes (DIO) play an important role in thyroid hormone metabolism. Among them, type 2 iodothyronine deiodinase (DIO2) converts T4 to T3 in brain and impaired psychological well-being was reported in minor variants of DIO2. However, the prevalence of three DIOs and their relation to neuropsychological status has not been evaluated in Asian hypothyroid subjects.Methods: We prospectively enrolled 196 subjects who were taking levo...

Objectives: Immune checkpoint inhibitors (ICIs) have demonstrated stunning effects in many cancer types albeit its immune-related adverse outcomes such as hypophysitis, adrenalitis, and thyroiditis. Despite the significant increase in ICIs use in Korea, there still is a lack of clarification about the actual prevalence and risk factors of ICI-associated thyroid diseases.Methods: In this nationwide cohort study, 12,079 lung cancer patients were extrapolat...